Best QB matchup: Eli Manning, Giants vs. Cowboys (26.2 FPPG). It’s yet another favorable matchup for Eli, who hasn’t reached 20 fantasy points in a game since Week 1 … against Dallas.

Best RB matchup: Andre Brown, Giants vs. Cowboys (24.1 FPPG). Yep, the Cowboys defense is that bad. Did you see what the Saints RBs did against Dallas in Week 10?

MORE FANTASY FOOTBALL: Week 12 QB ranks | RB rankings | RB, WR sleepers

Best WR matchup: Vincent Jackson, Buccaneers at Lions (30.3 FPPG). V-Jax won’t have to share many of these WR points with underwhelming No. 2 Tiquan Underwood. He could be the best fantasy WR in this game with Calvin Johnson facing off against Darrelle Revis.

Best TE matchup: Coby Fleener, Colts at Cardinals (14.7 FPPG). Fleener is coming off his best game of the season and faces a defense that has allowed 10 TD catches to TEs in as many games.

Best D/ST matchup: Cowboys at Giants (14.5 FPPG). Eli and the Giants have been a little better protecting the ball lately, and we don’t blame you if you don’t trust the Cowboys D anyway. Houston also has a great matchup against the Jaguars (13.4 FPPG), but we actually prefer the Ravens D/ST against the Jets (12.6 FPPG).

Best K matchup: Garrett Hartley, Saints at Falcons (12.1 FPPG). Hartley is already a must-start and looks even better Thursday night in the Georgia Dome against the Falcons, who have let kickers go 25-for-26 on FGs.